THE DEXTROMETHORPHAN FAQ

 ANSWERS TO FREQUENTLY ASKED QUESTIONS ABOUT DEXTROMETHORPHAN (DXM)

HTML Version 4.0

Copyright © 1997 William E. White All Rights Reserved


Table of Contents

1

Acknowledgements

 

2

Preliminary Information

2.1

Restrictions and Disclaimer

    Distribution Restrictions

    General Disclaimer

    How to Reach the Author

2.2

Why a DXM FAQ?

2.3

Keeping DXM Legal

2.4

How to Use This Document

 

3

DXM QuickFAQ

3.1

What is DXM?

3.2

You Mean I Can Get High Off Cough Syrup?

3.3

What Kinds of Cough Medicine are Safe?

3.4

What Happens if I Drink the Wrong Cough Syrup?

3.5

I'm Taking Other Drugs -- Can I Take DXM?

3.6

What's the DXM Trip Like?

3.7

How Much DXM Do I Take?

3.8

Is DXM Like Acid?

3.9

Is DXM Fun?

3.10

Is DXM Dangerous?

3.11

If DXM is Dangerous, Why Do It?

 

4

General Information About DXM

4.1

DXM Quick Reference Page

4.2

What is Dextromethorphan Hydrobromide (DXM)?

4.3

What is Dextromethorphan Polistirex?

4.4

What is Dextrorphan (DXO)?

4.5

Is DXM Enjoyable as a Recreational Drug?

4.6

Is DXM an Opiate?

4.7

Does Everyone Like DXM?

4.8

How Does One Obtain and Use DXM?

    Cough Syrups

    Gelcaps

    Tablets and Capsules (including Coricidin)

    Lozenges

    Pharmaceutical and Chemical Suppliers

    Extracted DXM

    Injection and Other Routes

4.9

What are Some Typical DXM-Containing Preparations?

4.10

How am I Supposed to Drink Cough Syrup?

4.11

What Should I Know About Other Drug Ingredients?

    Decongestants

    Antihistamines

    Guaifenesin

    Analgesics, Acetaminophen/Paracetamol

    Alcohol

    Food Coloring and Dyes

    Bromide Ions

    Other "Inactive" Ingredients

4.12

Why are So Many DXM Preparations in Liquid Form?

4.13

Is Recreational Use of DXM Illegal?

4.14

If DXM is Legal Why Isn't Everyone Doing It?

4.15

New Medical Uses for DXM

    Diagnostic Uses

    Neuroprotectant Uses

    DXM for Chronic Pain

    DXM for Drug Addiction

    DXM for Disease and Miscellaneous Conditions

4.16

Drug Interactions

    Fatal or Dangerous Interactions

    Beneficial Drug Interactions

    Recreational Drug Interactions

4.17

General Warnings

4.18

What About Other Cough Suppressants?

    Noscapine

    Opiates

    Topical Anaesthetics

    Can DXM be Detected on Drug Tests?

 

5

The DXM Experience

5.1

What is the General Character of the DXM Experience?

5.2

Overview of the Lower Plateaus

5.3

The First Plateau

    Sensory Effects

    Cognitive/Emotional Effects

    Motor Effects

    Memory Effects

5.4

The Second Plateau

    Sensory Effects

    Cognitive/Emotional Effects

    Motor Effects

    Memory Effects

5.5

The Transitional Phase

5.6

The Upper Plateaus

5.7

The Third Plateau

    Sensory Effects

    Cognitive/Emotional Effects

    Motor Effects

    Memory Effects

5.8

The Fourth Plateau

5.9

Plateau Sigma

5.10

Is There Anything Beyond the Fourth Plateau?

5.11

What is the "DXM Third Eye Camera"?

5.12

Tussin Space, Tussin Consciousness

5.13

What is the "Tussin Euphoria" and What Makes it Unique?

5.14

What Can Happen with Long-term or Regular Use?

5.15

Why does DXM Affect Different People So Differently?

5.16

How Does DXM Compare With Other Dissociatives?

 

6

DXM Side Effects and Other Things to Avoid

6.1

What are Some Minor Risks of Occasional Use?

    Nausea and Other Gastric Disturbances

    Dizziness

    Mild Allergic Reactions and Histamine Release

    Sexual Dysfunction

    Diaphoresis (sweating)

    Impaired Judgement and Mental Performance

    Hangovers

    Tachycardia (Increased Heart Rate)

    Pupil Dilation or Constriction

    Hot and Cold Flashes

    Facial Edema

    Mild Hypertension (High Blood Pressure)

    Mild Hyperthermia (Increased Temperature)

    Overexertion

    Urticaria (skin rash/wheal)

    Increased Bile Secretion

    Inappropriate Behaviour

    Miscellaneous

6.2

What are Some Major Risks of Occasional Use?

    Panic Attacks

    Psychotic Breaks

    Impaired Judgement in Critical Situations

    Depression

    Serious Hyperthermia (High Temperature)

    Serious Hypertension (High Blood Pressure)

    Rhabdomyolysis

    Respiratory Depression

    Serotonin Syndrome

    Major Allergic Reactions and Histamine Release

    Miscellaneous

6.3

What Are the Risks of Regular Use and Binges?

    NMDA Antagonist Neurotoxicity (Olney's Lesions)

    Cerebral Hemorrhage and Stroke

    Other Neurotoxicity Mechanisms

    Mania

    Depression

    Violent Ideations, Antisocial Behaviour, and Paranoia

    Memory Impairment

    Language Impairment

    Weight Loss

    Loss of Muscle Control

    Habituation and Psychological Addiction

    Tolerance and Physical Addiction

    Psychosis

    Liver, Kidney, and Pancreas Damage

    Bromide Poisoning

    Miscellaneous

    Summary: Regular Use Considered

6.4

DXM and Pregnancy

6.5

What is NMDA Antagonist Neurotoxicity and How do I Prevent It?

    Overview and Mechanism of Olney's Lesions

    Dosages at Which NAN Occurs

    Balancing the Risks: Is Olney's Research Relevant to DXM Use?

    A Look at the Areas Involved

    Preventing and Limiting NMDA Antagonist Neurotoxicity

6.6

Is DXM Addictive?

6.7

Is DXM Withdrawal Dangerous?

6.8

Kicking the DXM Habit: What to Do If You are Addicted

    Preparing to Quit

    Quitting "Cold Turkey"

    Build-Down

    After Quitting: When Can I Use DXM Again?

6.9

DXM Hangovers -- Avoiding and Alleviating

6.10

How Toxic is DXM, and What is the Lethal Dose?

6.11

Do You Recommend DXM for Recreational Use?

6.12

Help! What do I do if ...

    Itching (the "Robo Itch")

    Fast Heartbeat

    Panic Attacks

    Irregular or Skipped Heartbeats

    Nausea, Vomiting, Gas, and Diarrhea

    Unconsciousness

    Overdose

    High Temperature / Fever

    Shortness of Breath / Breathing Problems

    Choking On Your Tongue

    Nosebleeds

    Feeling "dead" / losing one's body

    Hangovers (lethargy and feeling "not all there")

    Prolonged Dissociation From the Real World

    Serotonin Syndrome

    Bad Trips

    Psychotic Breaks

6.13

How to Know When You've Done Too Much DXM

 

7

Getting the Most Out of DXM

7.1

General Tips on Enjoying the DXM Experience

7.2

What are Some Fun or Interesting Things to Do on DXM?

    Listen to Music

7.3

Watch a Movie

    Make Music

    Dance

    Swimming (First Plateau Only!)

    Group Tripping

    Paranormal/Spiritual Exploration

    Observe People

7.4

What Tools Can Enhance the DXM Experience?

    Sensory Deprivation

    Ganzfeld

    Light and Sound (Brainwave) Machines

    Hemisphere Synch Audio Tapes

    Trip Programs

    Trip Toys

7.5

What are Some Things to Avoid on DXM?

    Heavy Exercise

    Driving

    Going to Class, School, or Work on DXM

    Dose "Boosting" and Re-dosing

    Stressful Environments

7.6

What is the "50 Trip Limit" and How Can I Avoid It?

7.7

Why Can't I Hallucinate on DXM?

 

8

Altered States and Paranormal Experiences

8.1

Preliminary Information and Discussion

8.2

What Paranormal and Altered State Experiences Occur on DXM?

    The Dissociative Spiral

    Deja Vu and Other Memory Mishaps

    Out-of-Body Experiences (OOBEs)

    Near-Death and Rebirth Experiences

    Contact with Alien and Spiritual Beings

    Clairvoyance, ESP, and Other Psi Phenomena

    Memory Loops and Prescient Sensations

    Dissociative Thought Patterns

8.3

Cosmic Coincidence Central and the Alien Conspiracy

8.4

Are These Experiences Dangerous?

8.5

How Can These Be Explained

    Temporal Anomalies

    Complex Partial Seizures

    Influence of the Unseen Environment

    Spiritual Explanations

8.6

How do I Maximize Altered States and Paranormal Experiences?

    Theta Stimulation

    Hemisphere Synch Tapes

    Magnetic Stimulation

    Sensory Deprivation and Ganzfeld

    Predosing

    Meditation

8.7

Factors Affecting Susceptibility to Paranormal Experiences

8.8

A Warning About "Spiritual Shortcuts"

8.9

A Warning About Temporal Lobe Epilepsy

 

9

Physiological Effects of DXM

9.1

How Does DXM Inhibit the Cough Reflex?

9.2

How Does DXM Cause its Psychoactive Effects?

    General Information

    Contribution of the PCP2 Binding Site

    Contribution of the Sigma Binding Sites

    Contribution of the NMDA Receptor

    Temporal Lobe Involvement

    Contributions of Indirect Activity

    Flanging

    Hyper-Abstraction

    Delusions and Memory Problems

9.3

Why Does DXM Exhibit Plateaus?

    Plateaus 1-3: Multiple Receptors

    The Fourth Plateau: Sensory Shutdown

9.4

Why is This So Complicated?

9.5

Pharmacokinetics: How DXM is Metabolized

    Factors Affecting Metabolism of DXM

 

10

Neuropharmacology of DXM

10.1

What is a Receptor, Anyway? (Basic Neuropharmacology)

    The Structure of a Nerve Cell

    Neurotransmission

10.2

What are Sigma Receptors?

    Sigma 1 Receptors and General Sigma Information

    Sigma 2 Receptors

    Sigma 3 Receptors

10.3

What Are NMDA Receptors?

    NMDA and Other Glutamate Receptors

    NMDA Receptor Structure and Function

    NMDA Receptors and Excitotoxicity

10.4

What are PCP2 Receptors?

10.5

What are Na+ and Ca2+ Channels?

10.6

How Does DXM Compare to Other Dissociatives at These Receptors?

10.7

Endopsychosin and the Big Picture

 

11

DXM Chemistry and Extraction

11.1

How Can I Extract DXM From Cough Syrups and Gelcaps?

    Theory of Acid-Base Extractions

    Single-Phase Acid-Base Extraction of DXM

    Agent Lemon: Dual-Phase Acid-Base Extraction of DXM

    Precipitation Method

11.2

How Can I Get Rid of Other Drug Ingredients?

    Acetaminophen

    Guaifenesin

    Antihistamines and Decongestants

11.3

How Can I Test for Acetaminophen?

11.4

How do I Use Free Base DXM?

11.5

How Can I Synthesize DXM?

11.6

What Can I Synthesize From DXM?

    Dextrorphan

    Levorphanol / Levomethorphan

    3-Substituted Analogs

 

12

DXM Drug Culture

12.1

Is There, or Was There, a DXM Drug Culture?

    DXM in the 1960's

    DXM in the 1970's

    DXM in the 1980's

    DXM in the 1990's

    The Future of DXM Use

12.2

Why Haven't I Heard About DXM Drug Culture?

12.3

DXM "Drug Slang"

    Non-American DXM Drug Slang

12.4

How do I Tell My Friends I'm Getting High off Cough Syrup?

 

13

Mixing DXM and Other Drugs

13.1

Alcohol

13.2

Barbiturates and Benzodiazepines

13.3

Amphetamines and Other Psychostimulants

13.4

Cannabis (Marijuana)

13.5

LSD, Psilocybin (Shrooms), and Other 5HT Hallucinogens

13.6

Opiates

13.7

PCP and Ketamine

13.8

Nicotine

13.9

Phenethylamines (MDMA, MDA, 2CB, etc)

13.10

Nootropics (Smart Drugs)

13.11

Miscellaneous Other Drugs

 

14

DXM Experiences and Personal Reports

14.1

First and Second Plateau Experiences

    Positive Experiences

    Negative Experiences

14.2

Third and Fourth Plateau Experiences

    Positive Experiences

    Negative Experiences

14.3

Long Term Use Experiences

    Positive Experiences

    Negative Experiences

14.4

Multiple Drug Experiences

    DXM + Cannabis + Alcohol + Opium

    DXM + Cyclazine

    DXM + Mushrooms + LSD + Cannabis + Nitrous Oxide

 

15

Appendices

15.1

Appendix 1: P450 Inhibiting Drugs

15.2

Appendix 2: Neuropharmacology of Recreational Drugs

15.3

Appendix 3: Other Sigma and NMDA Ligands

 

16

Glossary

 

17

References